Alzheimer’s disease (AD) is a major neurological affliction that affects millions of people worldwide. Now, scientists at the Agharkar Research Institute in Pune have developed new types of molecules for the treatment of Alzheimer’s disease. These molecules are effective in treating this neurodegenerative disease and bring new hope for patients suffering from Alzheimer’s.
Alzheimer’s disease: A major neurological problem
Alzheimer’s is the most common form of dementia, accounting for close to 70 per cent of cases in old age. Worldwide, around 55 million people suffer from dementia, with the majority affected by Alzheimer’s. This disease occurs due to an imbalance of certain hormones in the brain, gradually impacting a person’s memory, thinking ability, and behaviour.
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High synthetic yield and new reaction technology
The team at the Agharkar Research Institute has developed new non-toxic molecules using synthetic, computational, and in-vitro studies. This process involves a fast one-pot, three-component reaction, enabling the production of high synthetic yield molecules. The efficacy and cytotoxicity of these molecules were tested using in-vitro screening methods.
Effect of molecules on cholinesterase enzymes
Scientists have found that these molecules are effective against cholinesterase enzymes, which increase the availability of acetylcholine, a chemical messenger in the body. This chemical helps improve memory and can be used to treat Alzheimer and Parkinson’s diseases. The molecules have also shown stability when in contact with amino acids, which is a significant indication of their effectiveness.
New possibilities for Alzheimer’s treatment
According to researchers, these molecules can be used to develop dual anti-cholinesterase drugs in combination with other medications for the treatment of Alzheimer’s disease. This could lead to more effective treatment options for Alzheimer’s and other neurodegenerative diseases.
Future looks bright for Alzheimer’s patients
Researchers believe that this discovery is a significant step forward in the treatment of Alzheimer’s disease. These new molecules can be further optimised to develop effective anti-AD ligands. This research by the Agharkar Research Institute is an inspiration to the global scientific community and could lead to even more significant breakthroughs in the future.
